Adam Hume

About

Work

Boston University Medical Campus
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Research Assistant Professor

US

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Boston University Medical Campus: Boston, MA, US
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Senior Research Scientist

US

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Boston University Medical Campus
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Research Scientist

US

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Boston University Medical Campus
|

Postdoctoral Associate

US

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Education

University of Wisconsin Madison
United States of America

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PhD

Bates College
United States of America

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Bachelor of Science

Publications

Harnessing Hazara Virus as a Surrogate for Crimean–Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level

Published by

Pathogens

Summary

journal-article

Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4′-fluorouridine

Published by

Antiviral Research

Summary

journal-article

Harnessing Hazara Virus as a Surrogate for Crimean–Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level

Published by

Pathogens

Summary

journal-article

A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses

Published by

Pathogens

Summary

journal-article

Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq

Published by

Viruses

Summary

journal-article

Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq

Published by

Viruses

Summary

journal-article

Improved protein splicing through viral passaging

Published by

mBio

Summary

journal-article

Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality

Published by

Pathogens

Summary

journal-article

Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality

Published by

Pathogens

Summary

journal-article

A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses

Published by

Microbiology Spectrum

Summary

journal-article

A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses

Published by

Pathogens

Summary

journal-article

Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers

Published by

Pathogens

Summary

journal-article

Minor intron–containing genes as an ancient backbone for viral infection?

Published by

PNAS Nexus

Summary

journal-article

Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae

Published by

Archives of Virology

Summary

journal-article

Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses

Published by

Pathogens

Summary

journal-article

Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses

Published by

Pathogens

Summary

journal-article

Isolation and genome characterization of Lloviu virus from Italian Schreibers’s bats

Published by

Scientific Reports

Summary

journal-article

Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers

Published by

Pathogens

Summary

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Published by

Microorganisms

Summary

journal-article

Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Published by

Microorganisms

Summary

journal-article

Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Published by

Nature Communications

Summary

journal-article

Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary (Nature Communications, (2022), 13, 1, (1706), 10.1038/s41467-022-29298-1)

Published by

Nature Communications

Summary

journal-article

Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary (Nature Communications, (2022), 13, 1, (1706), 10.1038/s41467-022-29298-1)

Published by

Nature Communications

Summary

journal-article

Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Published by

Nature Communications

Summary

journal-article

Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Published by

Nature Communications

Summary

journal-article

Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Published by

Nature Communications

Summary

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

Published by

American Journal of Physiology-Lung Cellular and Molecular Physiology

Summary

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

Published by

American Journal of Physiology - Lung Cellular and Molecular Physiology

Summary

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

Published by

American Journal of Physiology - Lung Cellular and Molecular Physiology

Summary

journal-article

Recombinant Lloviu virus as a tool to study viral replication and host responses

Published by

PLOS Pathogens

Summary

journal-article

Recombinant Lloviu virus as a tool to study viral replication and host responses

Published by

PLoS Pathogens

Summary

journal-article

Recombinant Lloviu virus as a tool to study viral replication and host responses

Published by

PLoS Pathogens

Summary

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Isolation and genome characterization of Lloviu virus from Italian Schreibers’ bent-winged bats

Summary

preprint

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

Published by

bioRxiv

Summary

other

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

Published by

bioRxiv

Summary

other

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

Published by

Stem Cell Reports

Summary

journal-article

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

Published by

Stem Cell Reports

Summary

journal-article

Erratum: Recombinant Lloviu virus as a tool to study viral replication and host responses (PLoS Pathogens (2022) 18:2 (e1010268) DOI: 10.1371/journal.ppat.1010268)

Published by

PLoS Pathogens

Summary

journal-article

Erratum: Recombinant Lloviu virus as a tool to study viral replication and host responses (PLoS Pathogens (2022) 18:2 (e1010268) DOI: 10.1371/journal.ppat.1010268)

Published by

PLoS Pathogens

Summary

journal-article

Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2

Published by

Angiogenesis

Summary

journal-article

Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2

Published by

Angiogenesis

Summary

journal-article

Reservoir host studies of Lloviu virus: first isolation, sequencing and serology in Schreiber’s bats in Europe

Summary

other

Reservoir host studies of Lloviu virus: First isolation, sequencing and serology in Schreiber's bats in Europe

Published by

bioRxiv

Summary

other

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

Summary

other

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

Published by

bioRxiv

Summary

other

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

Published by

bioRxiv

Summary

other

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response.

Published by

Stem cell reports

Summary

journal-article

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Published by

Stem Cell Reports

Summary

journal-article

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Published by

Stem Cell Reports

Summary

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

Published by

bioRxiv

Summary

other

Reservoir host studies of Lloviu virus: First isolation, sequencing and serology in Schreiber's bats in Europe

Published by

bioRxiv

Summary

other

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

Published by

bioRxiv

Summary

other

Ebola virus infection induces a type I interferon response and the shutdown of key liver functions in human iPSC-derived hepatocytes

Published by

ResearchSquare

Summary

other

Ebola virus infection induces a type I interferon response and the shutdown of key liver functions in human iPSC-derived hepatocytes

Published by

ResearchSquare

Summary

other

Erratum: Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 (Molecular Cell (2020) 80(6) (1104–1122.e9), (S1097276520308285), (10.1016/j.molcel.2020.11.028))

Published by

Molecular Cell

Summary

journal-article

Erratum: Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 (Molecular Cell (2020) 80(6) (1104–1122.e9), (S1097276520308285), (10.1016/j.molcel.2020.11.028))

Published by

Molecular Cell

Summary

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

Published by

bioRxiv

Summary

other

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

Published by

bioRxiv

Summary

other

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Published by

Molecular Cell

Summary

journal-article

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Published by

Molecular Cell

Summary

journal-article

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Published by

Molecular Cell

Summary

journal-article

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

Published by

Science

Summary

journal-article

MHC class II transactivator CIITA induces cell resistance to ebola virus and SARS-like coronaviruses

Published by

Science

Summary

journal-article

MHC class II transactivator CIITA induces cell resistance to ebola virus and SARS-like coronaviruses

Published by

Science

Summary

journal-article

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response.

Published by

Cell stem cell

Summary

journal-article

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Published by

Cell Stem Cell

Summary

journal-article

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Published by

Cell Stem Cell

Summary

journal-article

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Published by

Frontiers in Immunology

Summary

journal-article

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Published by

Frontiers in Immunology

Summary

journal-article

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Published by

Frontiers in Immunology

Summary

journal-article

Human Pluripotent Stem Cell Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Published by

SSRN

Summary

other

Human Pluripotent Stem Cell Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Published by

SSRN

Summary

other

Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection

Published by

bioRxiv

Summary

other

Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection

Published by

bioRxiv

Summary

other

SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response

Published by

bioRxiv

Summary

other

SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response

Published by

bioRxiv

Summary

other

SARS-CoV-2 spike protein interacts with multiple innate immune receptors

Published by

bioRxiv

Summary

other

SARS-CoV-2 spike protein interacts with multiple innate immune receptors

Published by

bioRxiv

Summary

other

Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family

Published by

Journal of Molecular Biology

Summary

journal-article

Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family

Published by

Journal of Molecular Biology

Summary

journal-article

Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family

Published by

Journal of Molecular Biology

Summary

journal-article

Recent advances in marburgvirus research [version 1; peer review: 3 approved]

Summary

journal-article

Recent advances in marburgvirus research

Published by

F1000Research

Summary

journal-article

Recent advances in marburgvirus research [version 1; peer review: 3 approved]

Published by

F1000Research

Summary

journal-article

Recent advances in marburgvirus research [version 1; peer review: 3 approved]

Published by

F1000Research

Summary

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism.

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism.

Summary

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity

Published by

Cell

Summary

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing.

Published by

PLoS pathogens

Summary

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing.

Summary

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing

Published by

PLoS Pathogens

Summary

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing

Published by

PLoS Pathogens

Summary

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses.

Published by

Cell reports

Summary

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses.

Summary

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses

Published by

Cell Reports

Summary

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses

Published by

Cell Reports

Summary

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner.

Published by

The Journal of infectious diseases

Summary

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner.

Summary

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner

Published by

Journal of Infectious Diseases

Summary

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner

Published by

Journal of Infectious Diseases

Summary

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

Published by

Cell

Summary

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

Summary

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity

Published by

Cell

Summary

journal-article

Filovirus strategies to escape antiviral responses

Published by

Current Topics in Microbiology and Immunology

Summary

book-chapter

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening.

Published by

Antiviral research

Summary

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening.

Summary

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening

Published by

Antiviral Research

Summary

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening

Published by

Antiviral Research

Summary

journal-article

Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages.

Published by

Journal of virology

Summary

journal-article

Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages.

Summary

journal-article

Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

Published by

Journal of Virology

Summary

journal-article

Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

Published by

Journal of Virology

Summary

journal-article

Filovirus Strategies to Escape Antiviral Responses.

Published by

Current topics in microbiology and immunology

Summary

journal-article

Filovirus Strategies to Escape Antiviral Responses.

Summary

journal-article

Filovirus strategies to escape antiviral responses

Published by

Current Topics in Microbiology and Immunology

Summary

book-chapter

Inactivation of RNA viruses by gamma irradiation: A study on mitigating factors

Published by

Viruses

Summary

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.

Published by

Journal of virology

Summary

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.

Summary

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions

Published by

Journal of Virology

Summary

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions

Published by

Journal of Virology

Summary

journal-article

Inactivation of RNA Viruses by Gamma Irradiation: A Study on Mitigating Factors.

Published by

Viruses

Summary

journal-article

Inactivation of RNA Viruses by Gamma Irradiation: A Study on Mitigating Factors.

Summary

journal-article

Inactivation of RNA viruses by gamma irradiation: A study on mitigating factors

Published by

Viruses

Summary

journal-article

Forty-five years of marburg virus research

Published by

Viruses

Summary

journal-article

Forty-five years of Marburg virus research.

Published by

Viruses

Summary

journal-article

Forty-five years of Marburg virus research.

Summary

journal-article

Forty-Five Years of Marburg Virus Research

Published by

Viruses

Summary

journal-article

Forty-five years of marburg virus research

Published by

Viruses

Summary

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.

Summary

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses.

Published by

Cell division

Summary

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses.

Summary

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses

Published by

Cell Division

Summary

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses

Published by

Cell Division

Summary

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.

Published by

Science (New York, N.Y.)

Summary

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.

Summary

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function

Published by

Science

Summary

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function

Published by

Science

Summary

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor

Published by

Toxicological Sciences

Summary

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor

Published by

Toxicological Sciences

Summary

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor.

Published by

Toxicological Sciences

Summary

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor.

Summary

journal-article